[Efficacy and safety of herbal drug, Hypericum perforatum in the treatment of premature ejaculation]

Premature ejaculation is the most prevalent form of male sexual dysfunction. Efforts to develop novel drugs safer than existing therapies are continued. Assessment of efficacy of Hypericum Perforatum in the treatment of premature ejaculation. This is the double blind, randomized placebo- controlled study. In this study were selected 50 married men [18-50 years old] who were referred to urology department of Razi hospital in Rasht from 2007 to 2008 with premature ejaculation were selected. These patients were divided to control and cases groups. Hypericum [160mg tablets] were prescribed for case group and placebo for control group. All participants completed IIEF-15 questionnaire before and after treatment. Intra vaginal latency time [IVLT] was measured before and after treatment. The results were analyzed using chi-square and paired t-test. After 4 weeks, there was difference in IVLT between 2 groups. This difference was statically significant [P<0.001]. There was an increase in two variables of the IIEF-15 [Intercourse satisfaction and overall satisfaction] in hypericum perforatum group [p<0.001]. In 3 participants drug was discontinued because of adverse reactions. It seems that hypericum perforatum may be regarded as a safe and effective alternative in the treatment of premature ejaculation

[Clinical signs, symptoms, diagnosis and outcomes of patients with complicated lung hydatid cysts]

Hydatid cysts caused by the Echinococcus Granulosus and Multilocularis. Liver and them lungs are the most common sites of lodgment of it. Because the clinical symptoms, diagnosis and outcome of treatment are not well discussed, we want to discussion this problem. Survey of the clinical signs, symptoms, diagnosis and outcomes of patients with complicated lung hydatid cysts. We retrospectively examined 54 records of patients with ruptured lung hydatid cyst in 152 patients who were hospitalized in Rasht hospitals, since 1993 to 2005, and were surgically treated. Data collection tools were a predetermined review form; and findings are presented in relative frequencies tables. 54 cases 38[70.3%] were male. Age rang of patients was 4-63 years. Chief complaints of the patients were cough in 47 cases [87%], dyspnea in 42[77.8%], sputum in 37[68.5%], chest pain in 31[57.5%], and hemoptysis in 13[24%]. Most common lodgment of cysts in the lungs was right lower lobe in 38[57.5%]. Ruptures occurred in tracheobronchial tree in 39[73%], and in pleural space in 10[23%]. Complication after surgery occurred in 15 patients. Three patients [5.5%] were needed reoperation for treatment: bronchopleural fistula treatment in two cases and bilio-pleural fistula in one case. After surgical treatment, 53 patients [98.1%] were completely cured; recurrence occurred in one patient [1.9%] who treated with Albendazol. There was no hospital mortality. In endemic area all cystic lesions of lung must be ruled out for hydatid cysts; because some patients with lung hydatid cysts present complications: the cause of complication are, lately referring to physician and delay in diagnosis. Early treatment with medical and surgical approach recommended

[Iron deficiency anemia and some associated factors in childbearing age women in Guilan province]

Iron deficiency anemia [IDA] is the commonest disorder due to malnutrition, and is an important health problem. This research determines IDA prevalence and some associated factors in childbearing age [CBA] and non-childbearing age women in Guilan. Sample; comprised of 995 CBA women [15-49 years], selected in a multistage cluster-random sampling from the population mentioned. Data materials included a questionnaire, and blood examinations, and statistical analysis was performed by means of paired t-test. Anemia prevalence was 11.1%, IDA 7.6%, which was similar in both the urban and rural population, and showed significant correlation with parity [P<0.0l] and age [P<0.0001]. Ferrous sulfate has significant effect to increase hemoglobin in IDA subjects. IDA prevalence in Guilan is less than previous estimates, and Ferrous sulfate administration is effective in increasing hemoglobin levels

Evidence suggesting that fasciola gigantica might be the most prevalent causal agent of fascioliasis in northern Iran

Following the occurrence of two large outbreaks in Gilan province, northern Iran, the public health importance of human fascioliasis has increased significantly. The mixed infections of Fasciola gigantica and F. hepatica within a given domestic animal individual suggest a very complicate picture of possible circulation ways of the parasite and the possibility for humans to be infected with both species. Elucidating these circulation ways is very critical for underst and ing the epidemiology and transmission of the disease and being ascertain how animals and humans enter the different liver fluke circulations in this endemic zone. The main objective of the present study was to investigate the distribution and natural infections of local lymnaeids, environmental characteristics related to the disease transmission and determining the most prevalent fasciolids and definitive hosts in human endemic areas of Gilan province. B and ar-Anzali and Rasht are the most important endemic areas with most of the cases of human disease during the epidemics and inter-epidemic periods. Sheep raising is not normal in these regions, while cattle is the most common definitive host. According to the data obtained from slaughterhouse observations in B and ar-Anzali and Rasht, the main fasciolid in local cattle is F. gigantica. Of 928 adult liver flukes collected from 13 infected livers of cattle, in Rasht and B and ar-Anzali slaughterhouses, 91.1% were diagnosed as F. gigantica and 8.9% as F. hepatica. L. gedrosiana and L. palustris were the most prevalent lymnaeid snails in this endemic zone. It appears that L. truncatula is not prevalent in B and ar-Anzali and Rasht and surroundings of these endemic cities. Of 4830 different snails studied, only seven L. gedrosiana were found to be infected with larval stages [rediae and cercariae] of Fasciola sp. Experimental infections of 15 common laboratory mice by metacercariae, obtained from those naturally infected snails, were carried out and all trematodes recovered at necropsy, 8 weeks post-exposure, appeared to be F. gigantica based on morphology. The high temperature, moisture and rainfall during the year, especially in B and ar-Anzali, support the establishment and transmission of the disease in the zone. Although the species involved in human infections in endemic areas of Gilan has been usually referred to as F. hepatica, the results of this study as well as some interesting epidemiological evidences related to the disease, support that Fasciola gigantica might be the main causal agent of fascioliasis in this important endemic zone